Analysis of latently infected HIV-1 circulating in Sub-Sahara Africa

2019 Fiscal Year Final Research Report

• Project/Area Number: 16H05822
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Virology
• Research Institution: Kumamoto University
• Principal Investigator: UENO Takamasa 熊本大学, ヒトレトロウイルス学共同研究センター, 教授 (10322314)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: HIV-1 / Sub-Sahara Africa

Outline of Final Research Achievements

Understanding of latently infected HIV-1 variants circulating in developing countries has remained obscure. In this study, in collaboration with Muhimbili University of Health and Allied Sicences (Tanzania), we established a prospective HIV cohort in Dar es Salaam, Tanzania and recrutited HIV positive patients at Muhimbili National Hospital and surrounding Care and Treament Center. We analyzed virological and epidemiological characteristics as well as drug-resistance patter of latenly infected HIV-1 provirsus circulating in Tanzania. Results obtained in this study could provide useful information and insights into HIV control in resource-limiting settings such as Sub-Sahara Africa.

Free Research Field

感染免疫学

Academic Significance and Societal Importance of the Research Achievements

抗ウイルス療法(ART)下で残存するHIV-1に関する途上国での情報は極めて乏しい。途上国においても多くの感染者がARTを受ける体制が整ってきており、本研究の成果はエイズが蔓延する地域におけるHIV医療の課題解決に貢献できる。