2018 Fiscal Year Final Research Report
Direct bioproduction of useful chemicals by displaying multi-functional cellulase on its cell surface
| Project/Area Number |
16H06132
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | バイオリファイナリー / 代謝工学 / 細胞表層工学 |
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| Outline of Final Research Achievements |
We developed useful chemicals producing microorganisms from cellulosic biomass. Based on the cell surface display techniques, we introduced beta-glucosidase on its cell surface, allowing to biomass assimilation abilities. Metabolic engineering also enabled improving productivities of L-lactic acid and 3-hydroxypropionic acid。Finally, we demonstrated direct LA and 3-HP production from cellobiose with high titer and yields.
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| Free Research Field |
生物化学工学
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| Academic Significance and Societal Importance of the Research Achievements |
低炭素社会の構築、エネルギー問題の解決に向け、再生可能な資源であるバイオマスの有効利用法の開発が急務である。代謝工学の発展とともに、新しい物質生産が可能になり、前処理バイオマスの酵素糖化技術も目覚しい発展を遂げている。しかし、バイオマス分解から物質生産までを一気に行う、といった極端な研究例が多く、本研究はこれら両者の要素技術の長所をうまく融合しようとする実例として意義がある。
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