Studies on biosynthesis of fairy chemicals on a novel purine metabolic pathway

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H06192
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied biochemistry
• Research Institution: Shizuoka University
• Principal Investigator: CHOI JAEHOON 静岡大学, 農学部, 助教 (40731633)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: フェアリーリング / フェアリー化合物 / 生合成 / 代謝 / 植物成長

Outline of Final Research Achievements

Fairy ring is a phenomenon in which the turf becomes darker than its surroundings. We discovered the plant growth regulators AHX and ICA from the Lepista sordida that causes fairy rings, and AHX and its in-plant metabolite AOH.It has been revealed that it is endogenously produced in plants and is biosynthesized by the novel purine metabolic pathwayBased on the above findings, we believe that AHX, ICA, and AOH (Fairy compounds) are likely to be new plant hormones. When the compound was extracted from the rice treated with the compound and analyzed by HPLC,it was revealed that a large number of metabolites were produced. Those compounds were isolated successfully and structural determination was performed. We continued research on elucidation of biosynthetic and metabolic pathways and identified biosynthetic enzymes of FCs.

Free Research Field

天然物化学

Academic Significance and Societal Importance of the Research Achievements

研究代表者らにより、フェアリーリングの正体はAHX、AOHとICAであることが世界で初めて明らかになった。さらに重要なことは、それらの化合物は既知の植物ホルモンとは全く違う挙動を示し、新しい作用機構による活性であることや、植物に内生していることから新しい植物ホルモンの可能性がある。そこに生合成や代謝経路が明らかになれば、新しい植物ホルモンとして位置づけられるであろう。さらに、植物生長剤としての実用化研究も内外の大手化学会社によって始まっており、これらの基礎研究は、実用化のためにも有意義な情報を与える。