Study of novel mechanisms of transcriptional regulation and lipid metabolism by FGF21

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06195
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: The University of Tokyo
• Principal Investigator: Shimizu Makoto 東京大学, 大学院農学生命科学研究科(農学部), 助教 (40409008)
• Co-Investigator(Renkei-kenkyūsha): SATO Ryuichiro 東京大学, 大学院農学生命科学研究科(農学部), 教授 (50187259)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: FGF21 / 脂肪肝 / PPARg

Outline of Final Research Achievements

FGF21 is an anti-obese hormone which is synthesized and secreted from the liver. In this study, mechanisms of regulation of fatty liver by FGF21, and transcriptional regulation of FGF21 gene by a novel transcription factor were analyzed. I found that FGF21 prevents fatty liver through a nuclear hormone receptor PPARg. I also found a resnpose element of a novel transcription factor on the FGF21 promoter, and induction of FGF21 gene by fatty liver is significantly decresed by its knockout mouse.

Free Research Field

食品科学