Characterization of gill epithelial antigen sampling cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H06201
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Aquatic bioproduction science
• Research Institution: Tokyo University of Marine Science and Technology
• Principal Investigator: Kato Goshi 東京海洋大学, 学術研究院, 助教 (50624219)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 粘膜免疫 / 浸漬ワクチン

Outline of Final Research Achievements

Bath-vaccination is a cost-effective technique to apply vaccines to fish. However, mechanisms of antigen uptake and immune recognition on the mucosal surfaces of fish are largely unknown. We have demonstrated that bacterial vaccine antigens are taken up by gill epithelial antigen sampling (GAS) cells. In this study, we showed that teleost GAS cells have functions in antigen processing and antigen presentation. These results may contribute to develop a new technique for fish bath-vaccination.

Free Research Field

魚類免疫学

Academic Significance and Societal Importance of the Research Achievements

浸漬ワクチンは、これまで限られた病原体に対してのみ使用可能であった。本研究では、鰓上皮抗原取込細胞によりワクチン成分が取り込まれるか否かにより、その浸漬ワクチンとしての有効性が担保される可能性を示した。今後、鰓上皮抗原取込細胞により取り込まれやすい細菌や取り込まれやすい分子を明らかにすることで、鰓上皮抗原取込細胞を標的とした新たな浸漬ワクチンの開発が期待される。