Study on skeletal muscle proteolysis due to systemic metabolic dysfunction in broiler chickens exposed to heat stress

2019 Fiscal Year Final Research Report

• Project/Area Number: 16H06205
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Animal production science
• Research Institution: Tohoku University
• Principal Investigator: Kikusato Motoi 東北大学, 農学研究科, 准教授 (90613042)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 暑熱ストレス / 筋タンパク質分解 / 全身性炎症 / 酸化ストレス / 肉用鶏

Outline of Final Research Achievements

This study was conducted to elucidate trans-organ metabolic network that induces muscle protein degradation in broiler chickens exposed to heat stress (HS). In the study, corticosterone (CORT), mitochondrial reactive oxygen species generation (mitROS), intestinal barrier function, inflammatory response, amino acid metabolism were evaluated. As a result, the study revealed that i) HS-induced muscle proteolysis could be attributed to mitROS rather than CORT, and that ii) LPS influx evoked by intestinal barrier dysfunction may stimulate 3-MH and CORT secretion, and iii) Arg generated by the muscle proteolysis might contribute to the amelioration of inflammation in HS-exposed broiler chickens. These findings suggest that HS-induced muscle proteolysis may occur in the systemic inflammation in broiler chickens.

Free Research Field

動物生産科学

Academic Significance and Societal Importance of the Research Achievements

これまでの暑熱ストレス研究は非常に多彩ではあったものの、酸化ストレスなどの単一の代謝変化の追究に固執した研究が多かった。本研究では、暑熱諸反応を臓器間代謝ネットワークの観点から体系的・統合的に紡ぎ合わせ、筋タンパク質分解と腸管機能、炎症反応の連関を実証した。これにより、家禽科学に対してストレス反応ネットワークの視点を提供し、また新たな暑熱ストレス制御法として腸管における抗炎症の生理的重要性を提示した。