Real-world registry studies to develop clinical evidence for difficult symptoms in patients with far-advanced cancer

2019 Fiscal Year Final Research Report

• Project/Area Number: 16H06239
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Epidemiology and preventive medicine
• Research Institution: Seirei Christopher University (2017-2019); Osaka City University (2016)
• Principal Investigator: Maeda Isseki 聖隷クリストファー大学, 看護学研究科, 臨床講師 (70706639)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: レジストリ研究 / 終末期がん患者 / 症状緩和

Outline of Final Research Achievements

Far-advanced or terminally-ill cancer patients frequently experience difficult symptoms including terminal delirium, refractory pain, nausea and vomiting. However, high-quality clinical evidence for these symptoms are scarce. In this real-world registry study, we indicated safety and effectiveness of the following pharmacological interventions for vulnerable patients with advanced cancer who received palliative care through inpatient palliative care teams, palliative care units, or psycho-oncology services: anti-psychotics administration for terminal delirium; olanzapine for nausea and vomiting; and naldemedine for opioid-induced constipation.

Free Research Field

緩和医療

Academic Significance and Societal Importance of the Research Achievements

本研究は、実施可能性や倫理的な観点からランダム化比較試験の実施が困難な終末期がん患者の重大症状に関する薬物治療のエビデンスを創出する試みである。本研究の成果は診療ガイドライン等への反映を通じ患者の終末期ケアの質の向上に貢献するものとなると共に、本研究を通じて国内の緩和ケア施設のネットワーク構築および多施設共同によるレジストリ研究の実施基盤が形成され、今後のこの分野でのエビデンス創出基盤が整備されたと言える。