Prediction of treatment efficacy of molecular targeted agents and molecular mechanisms of treatment resistance in renal cell carcinoma

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H06265
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: Sato Yusuke 東京大学, 医学部附属病院, 講師 (20372378)
• Research Collaborator: Ogawa Seishi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 腎癌 / ゲノム解析

Outline of Final Research Achievements

Surgical specimens and peripheral blood were obtained from RCC (renal cell carcinoma) patients who were treated at the University of Tokyo. Cell free DNA was extracted from peripheral blood. VHL gene mutations which were identical with that of tumor DNA were detected from preoperative cell free DNA in some cases, which were disappeared in postoperative cell free DNA.

Free Research Field

腎癌

Academic Significance and Societal Importance of the Research Achievements

腎癌は中高年に好発する癌であり、手術や薬物による治療が行われる。進行するまで症状を呈しないことが多く、診断や再発・転移の検出には課題もある。本研究では、血液中から取り出したDNAから、腎癌で生じている遺伝子変異が検出しうることが明らかになった。これにより、腎癌の診断や再発・転移の予測が行いやすくなることが期待される。