Comprehensive analyses of the interaction between host glycan and influenza viruses and its significance in virus infection

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06597
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Veterinary medical science
• Research Institution: National Institute of Advanced Industrial Science and Technology (2017); Hokkaido University (2016)
• Principal Investigator: Hiono Takahiro 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (00775819)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: インフルエンザウイルス / 鳥インフルエンザ / レクチンマイクロアレイ / 糖鎖生物学

Outline of Final Research Achievements

Influenza A virus is a glycan-associated pathogen. In the present study, we analyzed direct interactions of glycan and influenza viruses via HA and NA, as well as host glycome changes after virus infections. The methods for the evaluation of glycan binding the HA and substrate specificity of the NA were established in the present study. Also, the present study demonstrated various changes in host glycome after the influenza virus infection using lectin microarray technique.

Free Research Field

ウイルス学