Evaluationt of regeneration of periodontal tissue of antibacterial scaffold using Ag/nanocarbon and

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06604
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontology
• Research Institution: Hokkaido University
• Principal Investigator: Nishida Erika 北海道大学, 大学病院, 医員 (50779882)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 歯周組織再生 / スキャフォールド / ナノカーボン / 酸化グラフェン / 抗菌性 / Ag

Outline of Final Research Achievements

In this study, we aimed to demonstrate the periodontal regeneration effect by creating Ag supported nanocarbon scaffold. No cytotoxicity was observed in GO and Ag/GO scaffolds, and bacterial growth inhibitory effect was observed in Ag/GO scaffold in bacterial culture test. In the histological observation in rats, the biocompatibility of GO and Ag/GO scaffolds was better than that of collagen scaffolds. In dog extraction tooth extraction, there was no significant difference in bone regeneration at GO, Ag/GO scaffold.
From the above, it was suggested that the GO coating improves the properties of the scaffold and that the Ag/GO scaffold could exhibit antibacterial properties.

Free Research Field

歯周組織再生