2017 Fiscal Year Final Research Report
Identification of probiotic derived bioactive molecule and clarification of its recognition system and activation mechanisms of cell signaling
| Project/Area Number |
16H06607
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
|
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Keywords | 大腸癌 / プロバイオティクス / 腸内細菌 / 癌治療 |
|---|
| Outline of Final Research Achievements |
Ferrichrome was identified from culture supernatant of L. casei ATCC334 which exhibited the strong growth inhibition effect of colorectal cancer cells. The anti-tumor effect of ferrichrome was stronger than classical anti-tumor agents, including 5-FU and cisplatin, and the additional effect was observed when ferrichrome and these agents were treated to cancer cells simultaneously. Ferrichrome activated the endoplasmic reticulum stress pathway for its anti-tumor effects. The molecular simulation based on structure of ferrichrome showed the molecular targets of ferrichrome. Ferrichrome exhibited tumor suppressive effects in tumor model mice. The adverse events, including lethality, hepatic dysfunction and anemia, were not observed when tenfold of medicinal dose of ferrichrome was administrated daily for a week.
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| Free Research Field |
生物学
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