Development of LC-MS/MS methods to analyze lipid molecules that possess unique structures for the elucidation their functions

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06637
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Yamagata University (2017); Tohoku University (2016)
• Principal Investigator: ITO Junya 山形大学, 農学部, 研究支援者 (50781647)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 食品科学 / 過酸化脂質 / 糖化脂質 / 質量分析

Outline of Final Research Achievements

In this study, we analyzed "lipid molecules that possess unique structures" (i.e., squalene hydroperoxide, glycated lipids and plasmalogen) by LC-MS/MS analysis in the presence of alkali metal ions, since such methods were previously proved to be effective for the analysis of lipid hydroperoxides (e.g., fatty acid hydroperoxide). Since the analysis of these "lipid molecules that possess unique structures" were previously difficult to perform, the developed analytical methods are expected to greatly contribute to the elucidation of further functions and activities of such lipids in foods as well as in animals and humans.

Free Research Field

食品科学