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2017 Fiscal Year Final Research Report

Development of 3D in vitro angiogenesis model using curvature controlled scaffold

Research Project

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Project/Area Number 16H06686
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Takahashi Haruko  東京大学, 生産技術研究所, 特任助教 (70775767)

Project Period (FY) 2016-08-26 – 2018-03-31
Keywords血管新生 / 三次元組織モデル / 足場材料 / 曲率
Outline of Final Research Achievements

This study aims to develop three-dimensional in vitro angiogenesis model on microdevice chip. The microvessels of several sizes (120, 200, and 300 micrometer in diameter) were successfully prepared and angiogenesis was induced by addition of vascular endothelial growth factor (VEGF). Angiogenesis induction was characterized by the sizes of the prepared microvasculatures. Longer and larger neovascular vessels formed from host microvasculature with smaller diameters, while only small sprouts were detected from large microvasculatures. By observation of the angiogenesis models, we visualized 3D features of the angiogenic sprouting process and provide information on the dynamics of luminal formation.

Free Research Field

生体材料学

URL: 

Published: 2019-03-29  

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