Analysis of the brain mechanisms responsible for the estrogen-dependent female sexual behavior

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06742
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Integrative animal science
• Research Institution: Nippon Medical School (2017); The University of Tokyo (2016)
• Principal Investigator: Watanabe Youki 日本医科大学, 医学部, 助教 (50781788)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: エストロジェン / ロードシス / ChiP-seq

Outline of Final Research Achievements

The present study aimed to investigate the brain mechanism mediating the estrogen-dependent female sexual behavior. Previous studies suggested that estrogen control the female-sexual behavior via estrogen-receptor alpha (ERα) in the hypothalamic ventromedial nucleus (VMH). Thus, we focused on the ERα signaling in the VMH in the female rats. We successfully got the gene lists of the ERα binding genes in VMH by genome-wide chromatin Immunoprecipitation sequencing analysis (ChiP-seq). We will clarify the function of these genes in terms of sexual behavior.

Free Research Field

動物生産科学