2017 Fiscal Year Final Research Report
A trial of objective evaluation of pathophysiology in neurodegenetrative disease by two-dimensional measurement of eye movements
| Project/Area Number |
16H06752
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyorin University (2017)
The University of Tokyo (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 衝動性眼球運動 / 脊髄小脳変性症 / 神経変性疾患 / 臨床症状 / 眼と手の協同運動 / 運動制御 |
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| Outline of Final Research Achievements |
To clarify the role of the cerebellum in saccadic eye movements, we studied saccade in hereditary spinocerebellar degeneration (SCD) using oculomotor tasks, visual guided (VGS) and memory guided tasks (MGS), with targets presented in two dimensional directions. We studied saccade with a video-based eye tracker and compared the parameters of it between SCD and normal controls. We confirmed elongation of latency besides change of amplitude in VGS in SCD patients, it was related to clinical symptoms. Prolongation of latency in SCD patients in whom cerebellum cortex was mainly affected, suggested new role of cerebellum in the control of saccade. The existence of parameters related to clinical severity may enable us to evaluate the disease progress. Further we devised a system capable of simultaneously recording the trajectory of eye and hand movements when subjects performed a visually guided reaching task. We investigated how cerebellar disfunction affects the eye-hand coordination.
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| Free Research Field |
主に神経変性疾患における眼球や四肢の運動評価や、臨床神経生理学的解析
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