Histological and molecular biology of thermal laryngeal mucosal disorder and verification of therapeutic effect by G-CSF

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06758
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: Sato Taku 東京大学, 医学部附属病院, 特任臨床医 (50779808)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 熱性喉頭粘膜障害 / 顆粒球コロニー刺激因子 / G-CSF / サイトカイン / 熱傷 / 気道狭窄

Outline of Final Research Achievements

Thermal laryngeal mucosal disorders such as laryngeal scarring and narrowing of the airway caused by burns, radiotherapy, cauterization with surgical operation, etc. are clinically extremely difficult to treat. The purpose of this study is to elucidate the mechanism of thermal laryngeal tissue disorder and to investigate the effect of suppressing disorder by administration of granulocyte colony stimulating factor (GCSF) as clinically applicable therapy.
We were succeeded in making the model of thermal laryngeal mucosal disorder in histological and molecular biology. However, the substance with mucosal disorder inhibitory effect have not been found and it is a subject of future research.

Free Research Field

耳鼻咽喉科