The study on correlation between mechanical stress and morphological change of alveolar bone during bone regeneration

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06777
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ARAI Yuki 東京医科歯科大学, 歯学部附属病院, 医員 (70778654)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 歯槽骨再生 / RANKL結合ペプチド / BMP-2 / メカニカルストレス

Outline of Final Research Achievements

We have shown that RANKL-binding peptide has osteogenetic effect on alveolar bone by local administration with BMP-2. On the other hand, it is not clear whether mechanical stress influence morphological changes on alveolar bone during bone regeneration. In this study, we aimed to clarify the effect of mechanical stress by hyperocclusion on bone regeneration of alveolar bone. We investigated the effect of mechanical stress on the bone regeneration beside of the mice maxillary molar, using hyperocclusion mice model and RANKL binding peptide with BMP-2. In radiological and histological analysis, bone mineral density increased significantly with mechanical stress due to hyperocclusion.

Free Research Field

歯学・補綴系歯学