A novel mechanism of TMJ-OA based on lubricin metabolism regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06778
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: IKEDA Yuhei 東京医科歯科大学, 歯学部附属病院, 医員 (50778511)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 成長期 / 咀嚼刺激低下 / 変形性顎関節症 / ルブリシン

Outline of Final Research Achievements

It is noticeable that temporomandibular joint (TMJ) hypofunction through mastication during the growth period is related to the development and progression of TMJ-OA due to deformity of the joints, muscular weakness, instability, overloading and so on.
In this study, 5-week-old male rats received a powder diet and forced to move left their jaws from 9 weeks of age. Compared with the control group, there was a tendency to increase in superficial cartilage in the lateral side of the condyle with toluidine blue staining. It also showed a tendency to increase lubricin immunopositive sites in the same regions with immunohistochemistry of lubricin .

Free Research Field

歯科矯正学