Evaluation of porous luminal structure beta-TCP with growth factor and development of new bone substitute materials

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06780
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: IKAWA Takahiro 東京医科歯科大学, 大学院医歯学総合研究科歯周病学分野, 非常勤講師 (20780290)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 骨補填剤 / 歯周組織再生 / 再生医療 / インプラント / 成長因子

Outline of Final Research Achievements

Bone substitute materials are indispensable for periodontal regeneration and implant treatment. This study evaluated histologically localized ridge augmentation using different structures of β-TCP including luminal structure β-TCP blocks, dense β-TCP blocks, and β-TCP granule. Though we couldn't develop the new bone substitute materials, luminal structure may have a greater potential for new bone formation. We successfully showed that FGF-2 in gelatin/β-TCP sponges increased potential to support periodontal wound healing.

Free Research Field

歯周病