A role of actin remodeling in cortical interneuron for critical period plasticity

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06811
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Niigata University
• Principal Investigator: Hou Xubin 新潟大学, 医歯学総合研究科, 特任助教 (00584765)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 抑制性介在ニューロン / 細胞骨格 / 眼優位性可塑性 / 臨界期

Outline of Final Research Achievements

Binocular vision is established in the primary visual cortex (V1) through activity-dependent competition during early postnatal life. Ocular dominance plasticity accompanies with maturation of cortical GABA circuits. We have found that Otx2 homeoprotein regulates the critical period via promoting perineuronal nets (PNNs) formation that strengthened visual responses on parvalbumin-positive interneurons (PV-cells). Otx2-inducible actin reorganization factor, Coactosin play a constructive role in maturation of PV circuits, ultimately regulating the cortical milieu for plasticity.

Free Research Field

神経発生学、神経生理学