Development of novel phototriggered reactions and their application to biomolecule labeling

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06824
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Chemical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: Mishiro Kenji 金沢大学, 新学術創成研究機構, 助教 (60776079)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 光化学反応

Outline of Final Research Achievements

In this research we have accomplished two types of project using highly strained molecules. First project was the development of novel bioactive compounds having highly strained structure. We have succeeded to synthesis the desired product and analysed its activity and biodistribution using nuclear medicine method. We have obtained some important information for the medicinal chemistry using the strained structures. Second project was the development of novel phototriggered reactions using highly strained molecules. We have succeeded to develop a phototriggered dehydration condensation whose progress is completely controllable by ON/OFF states of the light irradiation. The result was published in Org. Lett. 2017, 4912.

Free Research Field

化学系薬学