Structural transition of de novo proteins and reconstruction of protein nanobuilding block complexes.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06837
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Bio-related chemistry
• Research Institution: Institute for Molecular Science (2017); Shinshu University (2016)
• Principal Investigator: KOBAYASHI Naoya 分子科学研究所, 協奏分子システム研究センター, 特任研究員 (60781945)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 人工蛋白質 / 蛋白質ナノブロック / 自己組織化 / 環境変化応答 / ダイナミクス解析

Outline of Final Research Achievements

The purposes of this research are to design environmental change responsive artificial proteins which dynamically changes the structure between monomer and dimer, to investigate association state of the proteins in response to environmental change, and to analyze the dynamics of self-assembled nanostructure formation by applying these environmental change responsive artificial proteins as protein nanobuilding blocks.
In particular, we aim to create and control protein nanostructures responding to environmental changes by development and analysis of artificial proteins and protein nanoblocks responsive to pH changes.

Free Research Field

タンパク質工学