Suppression of tumor metastasis based on the vascular homeostasis regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06841
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Shinshu University
• Principal Investigator: Tanaka Megumu 信州大学, 医学系研究科, 研究員 (90786401)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: アドレノメデュリン / 腫瘍血管新生 / 血管恒常性 / 転移前土壌 / リンパ節転移

Outline of Final Research Achievements

Adrenomedullin, a vasoactive peptide, and its receptor-modulating protein RAMP2 are expected to be therapeutic target for suppressing tumor metastasis. We established vascular endothelial cell-specific RAMP2 knockout mice (DI-E-RAMP2-/-) and lymphatic endothelial cell -specific RAMP2 knockout mice (DI-LE-RAMP2-/-), and evaluated the role of AM-RAMP2 system in tumor metastasis.
In DI-E-RAMP2-/-, primary tumor growth was suppressed, but lung metastasis was accelerated due to the disruption of vascular homeostasis. On the other hand, in DI-LE-RAMP2-/-, primary tumor growth was enhanced with accelerated tumor angiogenesis. We are now analyzing lymph node metastasis by tumor transplantation to the footpad.

Free Research Field

血管