2017 Fiscal Year Final Research Report
Research for the pathogenic mechanism using transgenic EB virus and humanized mice
| Project/Area Number |
16H06867
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
KIMURA Hiroshi 名古屋大学, 大学院医学系研究科, 教授 (30303621)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | EBV / ヒト化マウス |
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| Outline of Final Research Achievements |
Epstein-Barr virus (EBV) is a member of gamma-herpesvirus, associated with lymphoproliferative disorders (LPDs) and malignant tumors. EBV has been studied extensively in vitro, but its in vivo analysis has not been sufficient. In this study, we established the humanized mouse model which enabled pathological analysis in a physiological setting. Severely immunodeficient mice transplanted with cord blood infected with EBV in vitro efficiently developed lymphoproliferative disorder. These findings suggested that this animal model was available for research of the pathogenic mechanism.
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| Free Research Field |
ウイルス学
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