Generation of organometallic reagents through decarbonylation of esters

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06887
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Synthetic chemistry
• Research Institution: Kyoto University
• Principal Investigator: Nogi Keisuke 京都大学, 理学研究科, 助教 (60779148)
• Research Collaborator: YORIMITSU Hideki 京都大学, 大学院理学研究科, 教授 ; Otsuka Shinya 京都大学, 大学院理学研究科, 大学院生
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 遷移金属触媒 / 有機金属化合物

Outline of Final Research Achievements

We investigated decarbonylative transformations of esters to organometallic species such as organoboron or zinc compounds. During the investigation, instead of the target transformations, we succeeded in development of C-S bond cleaving transformations of aryl sulfoxides including Negishi-type arylation, Sonogashira-type alkynylation, Buchwald-Hartwig-type amination, Miyaura-type borylation. C-S bonds are considered as “inert” bond as same as C-O bonds, and our results would afford important perceptions for further investigation of C-S bond cleaving transformations.

Free Research Field

有機合成化学