2017 Fiscal Year Final Research Report
Screening of microorganisms metabolizing lipids aerobically under inhibition of be-ta oxidation and construction of oxidized lipid library
| Project/Area Number |
16H06893
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
Kishino Shigenobu 京都大学, 大学院農学研究科, 助教 (40432348)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 酸化脂質 |
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| Outline of Final Research Achievements |
Oxidative lipid metabolites are expected to have physiological functions. Expansion of lipid library was tried by two methods, 'conversion of original fatty acids by lipoxygenase and P450' and 'screening of microorganisms converting fatty acid oxidatively under inhibition of beta-oxidation. As a result of screening, the microorganism producing novel hydroxy fatty acid was obtained. In addition, it was revealed that hydroxy and oxo fatty acids from lactic acid bacteria were converted to novel epoxy fatty acids by P450 BM-3.
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| Free Research Field |
応用微生物学
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