2017 Fiscal Year Final Research Report
Elucidating the role of microRNA-33 in chronic inflammation, fibrosis, and heart failure
| Project/Area Number |
16H06900
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 心不全 / 線維化 / 動脈硬化 / microRNA |
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| Outline of Final Research Achievements |
MicroRNAs are small non-protein-coding RNAs (20-24 bp) that bind to specific mRNAs and inhibit translation or promote mRNA degradation. We have been focusing on miR-33 which decreases HDL-C and promotes atherosclerosis, and it is a potential therapeutic target against atherosclerosis. In this study, we clarified that miR-33 is also involved in heart failure. We used pressure-overload mouse model and found that miR-33 has roles dominantly in cardiac fibroblasts and is involved in cardiac fibrosis. The results show that atherosclerosis and heart failure share mechanisms that can be novel therapeutic targets.
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| Free Research Field |
循環器内科学
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