Elucidation of the mechanism in organ-specific reguation of thyroid hormone deiodinase

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06902
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Kyoto University
• Principal Investigator: Sakane Yoriko 京都大学, 医学研究科, 特定助教 (70781342)
• Research Collaborator: YAMAUCHI Ichiro
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 甲状腺ホルモン脱ヨード酵素 / 甲状腺ホルモン / 化合物ライブラリー

Outline of Final Research Achievements

Based on our progress last year, we published two articles. In one article, we demonstrated that LXRα which was expressed mainly in the liver regulated the transcription of thyroid hormone deiodinase type 1 (D1) and also demonstrated the crosstalk between LXRα and thyroid hormone receptor on the promoter region of human D1 gene. In the other article, we demonstrated that growth hormon regulated the concentration of thyroid hormone levels and only in thyroid cell lines, growth hormon increased the activity of thyroid hormone deiodinase type 2.
In addition, to investigate novel regulators of the activity of thyroid hormone deiodinases we started to establish new promoter assay system using chemical library.

Free Research Field

内分泌