Computational modeling of thrombus formation in coiled cerebral aneurysms

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06917
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: Otani Tomohiro 大阪大学, 基礎工学研究科, 助教 (40778990)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 脳動脈瘤 / 数値流体計算 / 直交格子法 / コイル塞栓術 / 血栓

Outline of Final Research Achievements

This study developed a computational framework to analyze the blood flow characteristics in densely coiled cerebral aneurysms and a numerical model of the thrombus formation in the coiled aneurysm by representing the mechanical interaction between the thrombus formation and blood flow stagnation. The computational framework allowed us to estimate effects of coil packing density and configurations on the extent of blood flow stagnation in the aneurysm statistically. Furthermore, the phenomenological model of the thrombus formation successfully expressed effects of the coil configuration on the extent of thrombus formation in densely coiled aneurysms.

Free Research Field

計算バイオメカニクス