Development of Catalytic Reaction Mediated by Early Transition Metal via Sigma-bond Metathesis Reaction

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06934
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Osaka University
• Principal Investigator: Nagae Haruki 大阪大学, 基礎工学研究科, 助教 (40779005)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: C-H結合活性化 / 前周期遷移金属 / アミノアルキル化反応 / アミド錯体 / アルキル錯体

Outline of Final Research Achievements

The target of this research is development of catalytic C-H bond functionalization mediated by early transition metal complexes which show unique reactivity via σ-bond metathesis reaction. In 2016, I optimized reaction conditions, in which a combination of an trialkylyttrium complex and a bidentate ligand, N,N’-bis(2,6-diisopropylphenyl)ethane-1,2-diamido, showed the highest catalytic activity toward ortho C-H bond aminoalkylation reaction of 2-substituted pyridine derivatives. Based on this result, I am planning to screen chiral bidentate ligands to achieve chiral aminoalkylation reaction.

Free Research Field

有機金属