Examine the effect of HMGB1 on bone marrow derived mesenchymal stem cell

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06991
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Okayama University
• Principal Investigator: Komi Keiko 岡山大学, 大学病院, 医員 (80782028)
• Research Collaborator: KUBOKI Takuo ; AKIYAMA Kentaro ; ONO Mitsuaki ; MARUHAMA Kotaro ; YOSHIOKA Yuya ; KUNITOMO Masayoshi
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 間葉系幹細胞 / 組織再生 / 創傷治癒

Outline of Final Research Achievements

In recent years High mobility group box 1 (HMGB 1) is known as a factor promoting tissue regeneration. It is also reported that HMGB1 induces mesenchymal stem cells in the marrow to the damage skin. In this study, we investigated the influence of HMGB1 on bone marrow derived mesenchymal stem cells. In the mouse wound healing model, host mesenchymal stem cell accumulation was detected in 1 day after surgery, and HMGB1 was expressed around the stem cell accumulation site in same day. We examined the effect of HMGB1 on mesenchymal stem cells, but the effect on stemness, stem cell proliferation and migration was not clear. Further studies on multiple differentiation and immunomodulate function that may be affected in the presence of HMGB1 will be necessary in the future.

Free Research Field

歯科補綴学