2017 Fiscal Year Final Research Report
Midkine promotes oral cancer bone pain and progression
| Project/Area Number |
16H06992
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Okui Tatsuo 岡山大学, 大学病院, 助教 (40610928)
|
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 癌性骨痛 |
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| Outline of Final Research Achievements |
we studied cancer bone pain in an intratibial mouse xenograft model that employs midkine positive human oral cancer cells.Mice intratibially injected with midkine positive oral cancer cells SAS developed characteristic osteolytic lesions on X-ray photograph.
Midkine antagonist iMDK dramatically reduced cancer bone pain and progression of cancer cells in bone in mouse model. MIdkine antagonist iMDK dramatically suppressed osteoclast differentiation from bone marrow cells via vitamin D3 and MCSF stimulation.
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| Free Research Field |
癌骨破壊
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