Altered neural basis of vulnerability in recurrent depression

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07011
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Clinical psychology
• Research Institution: The University of Tokushima
• Principal Investigator: Yamamoto Tetsuya 徳島大学, 大学院社会産業理工学研究部(社会総合科学域), 特任講師 (60779396)
• Co-Investigator(Renkei-kenkyūsha): YOSHIMOTO Junichiro 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (10403346)
• Research Collaborator: Siegle Greg J. ; TAKAMURA Masahiro
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 抑うつ / fMRI / 機械学習 / 再発 / 感情 / 扁桃体 / DLPFC / 気分誘導

Outline of Final Research Achievements

To identify abnormal neural patterns related to the experience of a major depressive episode, we performed functional magnetic resonance imaging (fMRI) experiments using cognitive tasks in participants with depression and remission in depression. The patients with major depressive disorder showed specific brain activity during recall of happy/negative memories, compared to the healthy participants. Furthermore, the patients who had experienced multiple episodes showed distinctive functional connectivity patterns in (a) the cluster related to self/executive function and (b) the cluster related to the emotional system, compared to the patients who had experienced a single episode.

Free Research Field

臨床心理学