Development of novel multi-functionalized micelles and their biological application

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07030
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Polymer chemistry
• Research Institution: Kochi University
• Principal Investigator: NIKO Yosuke 高知大学, 教育研究部総合科学系複合領域科学部門, 助教 (20782056)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 高分子合成 / ミセル / 蛍光 / ポリ（2－エチル―2－オキサゾリン）

Outline of Final Research Achievements

In this research, we synthesized a novel surfactant based on poly(2-ethyl-2-oxazoline). The surfactant has a lot of hydrazide groups at water soluble part, therefore, it could undergo cross-link reaction with glutaraldehyde in micelles form. In addition, the surfactant possesses squarain dyes at hydrophobic part. The dyes in micelles core were normally not fluorescent due to H-aggregation but showed turn on fluorescence in reseponse to the collapse of micelles triggered by acid. These features of the micelles would be expected to be useful for theranostics.

Free Research Field

光機能性物質