2017 Fiscal Year Final Research Report
Development of animal models for anti-neurofascin 155 antibody-positive inflammatory demyelinating diseases by single chain antibodies
| Project/Area Number |
16H07051
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
Ito Yuji 鹿児島大学, 理工学研究科, 教授 (60223195)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 慢性炎症性脱髄性多発根ニューロパチー / neurofascin 155 / 自己抗体 / フラグメント抗体 / ランビエ絞輪 |
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| Outline of Final Research Achievements |
It has been reported that a subset of chronic inflammatory demyelinating polyneuropathy (CIDP) has autoantibodies against neurofascin 155 (NF155). However, pathogenicity of the antibodies remains to be elucidated. In this study, we aimed to isolate pathogenic single chain variable fragments against NF155 to elucidate pathomechanisms of anti-NF155 antibody-positive CIDP. We constructed an immunoglobulin V-gene phage-display library from the immunoglobulin repertoire of a patient with anti-NF155 antibody-positive CIDP. Then several antigen-specific clones were isolated using a cell panning method.
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| Free Research Field |
神経内科
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