2017 Fiscal Year Final Research Report
The role of vasospasm on the development of osteonecrosis of the femoral head
| Project/Area Number |
16H07057
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 大腿骨頭壊死症 / 大腿骨頭軟骨下脆弱性骨折 / 急速破壊型股関節症 / 関節液 / サイトカイン |
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| Outline of Final Research Achievements |
This study investigated the correlation between the degree of synovitis of the hip joint and expression of cytokine or bone metabolism marker in fluid of the hip joint, including TNF-α, IL-6, IL-1β, IL-8, MMP-3, MMP-9, BAP and TRACP5b in patients with osteonecrosis of the femoral head. There were significant correlation between the degree of the synovitis and the expression of IL-8 or TRACP5b, which indicate that synovitis plays an important role on the vascularization or bone resorption in patients with osteonecrosis of the femoral head. Regarding the subchondral insufficiency fracture of the femoral head similar to osteonecrosis of the femoral head, the levels of expression of IL-8, TRACP-5b, VEGF, MMP-9 in cases with progressive collapse were significantly higher than those in cases without progressive collapse, which indicate that increased osteoclast activity may be result of progressive collapse in subchondral insufficiency fracture of the femoral head.
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| Free Research Field |
股関節、大腿骨頭壊死症
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