2017 Fiscal Year Final Research Report
Elucidation of COMMD1 effect in HIV-1 latent infection establishment
Project/Area Number |
16H07080
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Virology
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Research Institution | Kumamoto University |
Principal Investigator |
Kudo Eriko 熊本大学, エイズ学研究センター, 特定事業研究員 (00779176)
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Project Period (FY) |
2016-08-26 – 2018-03-31
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Keywords | HIV-1 / HIV-1宿主因子 / 潜伏感染 / COMMD1 / 転写制御 |
Outline of Final Research Achievements |
The effect of HIV-1 host factors has identified in primary infection. However, the effect in latent infection establishment is unknown. COMMD1 inducible cell line suppressed HIV-1 replication and decreased integrated HIV-1 genome. HIV-1 latently infection establishment and reactivation effect were similar between COMMD1 high and low expressed cells. Moreover, -1kbp COMMD1 promoter construct has highest activity in both myeloid and lymphoid cells. Therefore, this study indicates that COMMD1 doesn’t have effect for HIV-1 latent infection establishment and transcriptional regulation in myeloid cells was regulated in a further upstream.
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Free Research Field |
ウイルス学
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