Elucidation of COMMD1 effect in HIV-1 latent infection establishment

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07080
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Virology
• Research Institution: Kumamoto University
• Principal Investigator: Kudo Eriko 熊本大学, エイズ学研究センター, 特定事業研究員 (00779176)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: HIV-1 / HIV-1宿主因子 / 潜伏感染 / COMMD1 / 転写制御

Outline of Final Research Achievements

The effect of HIV-1 host factors has identified in primary infection. However, the effect in latent infection establishment is unknown. COMMD1 inducible cell line suppressed HIV-1 replication and decreased integrated HIV-1 genome. HIV-1 latently infection establishment and reactivation effect were similar between COMMD1 high and low expressed cells. Moreover, -1kbp COMMD1 promoter construct has highest activity in both myeloid and lymphoid cells. Therefore, this study indicates that COMMD1 doesn’t have effect for HIV-1 latent infection establishment and transcriptional regulation in myeloid cells was regulated in a further upstream.

Free Research Field

ウイルス学