2017 Fiscal Year Final Research Report
Validation of new markers for Intraductal papillary mucinous neoplasms based on the tumorigenic mechanism.
| Project/Area Number |
16H07095
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 膵管内乳頭粘液性腫瘍 / 遺伝子改変マウス / GNAS / IL-1ファミリー / SOX転写因子 |
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| Outline of Final Research Achievements |
I established a new mouse model in which pancreas-specific development of Intraductal papillary mucinous neoplasms (IPMNs) were obtained by induction of the mutant GNAS and detected molecules which were regulated by the mutant GNAS. This study was conducted to evaluate the importance of the molecules regulated by the mutant GNAS and validate the effectiveness as new markers for therapy and diagnosis of human IPMNs.
Further analysis of the molecules in the mouse system, an interlukin-1 family and a SOX transcription factor were identified to be analyzed in human system. The analysis in human system including patient-derived tissues of IPMNs, normal human pancreatic duct epithelial cells and human pancreatic cancer cells was conducted.
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| Free Research Field |
消化器外科学、膵臓外科学、分子腫瘍学、細胞生物学
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