2017 Fiscal Year Final Research Report
Identification and function of circular RNAs in diffuse-type gastric cancer
| Project/Area Number |
16H07123
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Katsutoshi Shoda 京都府立医科大学, 医学部附属病院, 研究員 (70783421)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 環状RNA / びまん性胃癌 |
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| Outline of Final Research Achievements |
In recent years, through development of next generation sequencer, it has been confirmed that hundreds of circular RNAs are expressed in humans and function pathophysiologically.
To identify circular RNA that is specifically expressed in diffuse-type gastric cancer, we conducted comprehensive analysis of circular RNA and compared the expression between cancer and noncancerous tissue in patients with diffuse-type gastric cancer. In diffuse stomach cancer, circular RNA in cancer tissues was significantly decreased as compared with noncancerous tissues, suggesting the possibility of functioning as a sponge of cancer related micro RNA.
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| Free Research Field |
消化器外科
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