2017 Fiscal Year Final Research Report
Role of Tenascin X and Decorin in the development of choroidal neovascularization and fibrosis.
| Project/Area Number |
16H07135
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Keywords | 滲出型加齢黄斑変性 / 脈絡膜新生血管 |
|---|
| Outline of Final Research Achievements |
Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness in older people in developed countries. Choroidal neovascularization (CNV) and associated fibrotic tissue formation around CNV are the major features of the exudative form of AMD.It has been reported that extracellular matrix was involved in CNV and fibrotic tissue formation. We investigated the function of tenascin-X and decorin in an in vivo mouse laser induced CNV model. CNV in decorin KO mice was tend to be larger than that of WT mice. There is not significantly difference on the CNV formation between in tenascin-X KO mice and in WT mice.
|
| Free Research Field |
脈絡膜血管新生
|
