2017 Fiscal Year Final Research Report
Development of novel treatment for rare cancer "Alveolar soft part sarcoma"
Project/Area Number |
16H07186
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
|
Research Institution | Juntendo University |
Principal Investigator |
|
Project Period (FY) |
2016-08-26 – 2018-03-31
|
Keywords | 胞巣状軟部肉腫 / チロシンキナーゼ / チロシンキナーゼ阻害剤 / 悪性骨軟部腫瘍 / 希少がん |
Outline of Final Research Achievements |
The aim of this study is developing a novel treatment for alveolar soft part sarcoma, which is a rare malignant tumor. We identified multiple tyrosine kinases, which are related to the mechanism of tumor development. We pre-clinically examined anti-tumor effect against alveolar soft part sarcoma by using tyrosine kinase inhibitor. As a result, Cabozantinib and Dasatinib showed significant anti-tumor activity both in vitro and in vivo. These results indicate that identified tyrosine kinases in this study are promising therapeutic target and these tyrosine kinase inhibitors can be a potent new therapeutic option.
|
Free Research Field |
整形外科、腫瘍
|