2017 Fiscal Year Final Research Report
Mechanisms of Cdc42 during cartilage development
| Project/Area Number |
16H07199
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|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontics/Pediatric dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
NAGAHAMA RYO 昭和大学, 歯学部, 助教 (90783530)
|
|---|
| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Keywords | 細胞内シグナル |
|---|
| Outline of Final Research Achievements |
To investigate the function of low molecular G protein Cdc42 on chondrogenesis during the postnatal growth phase, Cdc42 conditional knockout mice (Cdc42 cKO) in which Cdc42 is specifically deleted by tamoxifen administration was prepared. The body length and body weight of Cdc42 cKO mice were lower than those of control mice. Abnormal cartilage tissues were observed in long bone growth plates of Cdc42 cKO mice. These results suggest that Cdc42 plays an important role in cartilage formation during postnatal growth period.
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| Free Research Field |
骨代謝
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