Effect of probiotics on diarrhea focusing on aquaporin in the colon

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07253
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Hoshi University
• Principal Investigator: Risako Kon 星薬科大学, 先端生命科学研究所, 特任助教 (90779943)
• Research Collaborator: Ikarashi Nobutomo 星薬科大学, 薬動学教室, 講師
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: プロバイオティクス / 腸内細菌 / アクアポリン / 下痢

Outline of Final Research Achievements

In this study, we aimed to clarify the effectiveness and characteristics of probiotics, focused on the water channel “aquaporin (AQP)” in the colon. When the antibiotic was administered to rats, it was found the expression level of AQP3 decreased with increasing fecal water content. This action was not influenced by the antibiotic itself but occurs with a decrease in the amount of intestinal microbiota. Furthermore, the effect of probiotics on antibiotic-associated diarrhea was examined. As a result, Bifidobacterium infantis had not effect, whereas Bifidobacterium longum improved diarrhea and decreasing AQP3 by antibiotics administration.

Free Research Field

消化管

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、腸内細菌は大腸AQP3の発現量を制御しており、プロバイオティクスの特徴を説明する上で、大腸AQP3の発現や機能がバイオマーカーとなり得る可能性が示唆された。今後、詳細な解析を行うことにより、プロバイオティクスの特徴や有効かつ安全な使用法について社会に明示できるものと考えられる。