Development of polymeric materials with a highly sensitive mechanoprobe based on charge-transfer interaction and application to mechanobiology

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07292
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Polymer chemistry
• Research Institution: Waseda University
• Principal Investigator: Imato Keiichi 早稲田大学, 理工学術院, 助教 (80777970)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Naoya 早稲田大学, 理工学術院先進理工学部, 教授 (60338978)
• Research Collaborator: NAKAJIMA Hidekazu
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 高分子材料 / メカノケミストリー / メカノクロミズム / メカノバイオロジー / 自己修復 / 電荷移動相互作用

Outline of Final Research Achievements

In this study, we tried to develop a highly sensitive mechanoprobe based on charge transfer (CT) interaction between fluorescent molecules that reversibly dissociate and associate, and incorporate it into polymer chains, in order to reversibly detect microstress in polymeric materials. The designed probe and polymeric materials with it were successfully synthesized, but the reversible detection of microstress could not be achieved. On the other hand, when CT interaction was utilized as reversible physical cross-linking points in polymeric materials (elastomers), the elastomers showed self-healing in mild environments and could be used as cell culture scaffolds.

Free Research Field

高分子化学