2017 Fiscal Year Final Research Report
Exploratory research of therapeutic agents for neurodegenerative diseases based on clearance of alpha-synuclein
| Project/Area Number |
16H07341
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | α-シヌクレイン / DJ-1 / 神経細胞 / ミクログリア / NF-κB / オートファジー |
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| Outline of Final Research Achievements |
Preceding studies showed that α-synuclein (α-syn) was accumulated in neurons and extracellular α-syn bound to microglia and caused inflammation in the brain of patients with synucleinopathy. In this study, I investigated the effects of DJ-1 which is one of the causative genes of Parkinson's disease to cell responses induced by α-syn. I revealed that intracellular aggregation of α-syn was increased in the DJ-1 deficient SH-SY5Y cells compared with WT cells. Furthermore, I found that compounds predicted to bind to DJ-1 attenuated the inflammatory response in Microglia. These data suggest that DJ-1 can be a therapeutic target for neurodegenerative disease caused by α-syn.
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| Free Research Field |
薬理学、神経科学、神経免疫学
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