2017 Fiscal Year Final Research Report
Development suppression method for the scar after cleft palate repair by applying TGF-beta trapping function of microfibril assembly component MAGP-1
| Project/Area Number |
16H07388
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 矯正歯科 / 線維芽細胞 / 口蓋裂 / 瘢痕組織 / microfibril / TGF / MAGP-1 |
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| Outline of Final Research Achievements |
Cleft palate surgery suppresses the growth of the maxilla and makes it difficult to align the teeth. In order to cure surgical wounds, fibroblasts produce a large amount of collagen by anti-inflammatory cytokine TGF-β and form scars. Recently, it was reported that TGF-β is suppressed by binding to MAGP-1 which forms microfibril in somatic connective tissue. Therefore, it was thought that administeration of MAGP-1 to cleft surgical wounds could inhibit scar formation. Currently, we have prepared an in-vitro scar model with human gingival fibroblasts cultured in extensible mechanical stimulation, and found that the cells significantly increase MAGP-1 gene expression by extensible mechanical stimulation.
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| Free Research Field |
矯正歯科学
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