Development of New Catalyst for asymmetric C-H functionalization

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07402
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Kochi National College of Technology
• Principal Investigator: SHIRAI Tomohiko 高知工業高等専門学校, ソーシャルデザイン工学科, 助教 (80784644)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 不斉ヒドロアリール化 / カチオン性イリジウム

Outline of Final Research Achievements

Enantioselective transformations through the activation of C-H bond depict a potential to become an ideal tool for the synthesis of chiral building blocks. We investigate an efficient and highly enantioselective direct alkylation process for acetanilides that use 2-norbornene with a bis(phosphoramidite)-cationic Ir catalytic system (up to 99% ee). This methodology allows the facile preparation of enantiomerically enriched exo-2-(bicyclo[2.2.1]heptan-2-yl)aniline, which can be readily transformed into other functionalities.

Free Research Field

有機化学