2017 Fiscal Year Final Research Report
Development of 18F-labelled phosphonium derivatives for tumor imaging
Project/Area Number |
16H07431
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Radiation science
|
Research Institution | Southen Tohoku Research Institute for Neuroscience |
Principal Investigator |
Tominaga Takahiro 一般財団法人脳神経疾患研究所, 南東北創薬・サイクロトロン研究所, 助手 (50778602)
|
Co-Investigator(Renkei-kenkyūsha) |
FURUMOTO Shozo 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198)
|
Project Period (FY) |
2016-08-26 – 2018-03-31
|
Keywords | 腫瘍イメージング / ミトコンドリア / ホスホニウム / PET |
Outline of Final Research Achievements |
In this study, we evaluated 18F-labeled phosphonium derivatives as a tumor imaging agent. We synthesized various phosphonium derivatives and performed biological evaluation. Among them, 18F-TAP-D was selected as a candidate for a tumor imaging agent. In the cellular uptake study, good uptake of 18F-TAP-D was observed in tumor cells. However, we could not confirm the specific radioactivity accumulation to the tumor in the PET study with tumor-bearing mice.
|
Free Research Field |
放射性医薬品学
|