Development of 18F-labelled phosphonium derivatives for tumor imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07431
• Research Category: Grant-in-Aid for Research Activity start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Southen Tohoku Research Institute for Neuroscience
• Principal Investigator: Tominaga Takahiro 一般財団法人脳神経疾患研究所, 南東北創薬・サイクロトロン研究所, 助手 (50778602)
• Co-Investigator(Renkei-kenkyūsha): FURUMOTO Shozo 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 腫瘍イメージング / ミトコンドリア / ホスホニウム / PET

Outline of Final Research Achievements

In this study, we evaluated 18F-labeled phosphonium derivatives as a tumor imaging agent. We synthesized various phosphonium derivatives and performed biological evaluation. Among them, 18F-TAP-D was selected as a candidate for a tumor imaging agent. In the cellular uptake study, good uptake of 18F-TAP-D was observed in tumor cells. However, we could not confirm the specific radioactivity accumulation to the tumor in the PET study with tumor-bearing mice.

Free Research Field

放射性医薬品学