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2017 Fiscal Year Final Research Report

Development of 18F-labelled phosphonium derivatives for tumor imaging

Research Project

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Project/Area Number 16H07431
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionSouthen Tohoku Research Institute for Neuroscience

Principal Investigator

Tominaga Takahiro  一般財団法人脳神経疾患研究所, 南東北創薬・サイクロトロン研究所, 助手 (50778602)

Co-Investigator(Renkei-kenkyūsha) FURUMOTO Shozo  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198)
Project Period (FY) 2016-08-26 – 2018-03-31
Keywords腫瘍イメージング / ミトコンドリア / ホスホニウム / PET
Outline of Final Research Achievements

In this study, we evaluated 18F-labeled phosphonium derivatives as a tumor imaging agent. We synthesized various phosphonium derivatives and performed biological evaluation. Among them, 18F-TAP-D was selected as a candidate for a tumor imaging agent. In the cellular uptake study, good uptake of 18F-TAP-D was observed in tumor cells. However, we could not confirm the specific radioactivity accumulation to the tumor in the PET study with tumor-bearing mice.

Free Research Field

放射性医薬品学

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Published: 2019-03-29   Modified: 2020-03-30  

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