Hippocampal-retrosplenial-prefrontal interactions in temporal coding for configural associative memory

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07444
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Experimental psychology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Terada Satoshi 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (80780387)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 海馬 / 前頭前皮質 / 膨大後部皮質 / 形態化連合 / 時間符号化

Outline of Final Research Achievements

Little is known about how retrosplenial cortex (RSC) and prefrontal cortex (PFC) interact with hippocampus (CA1) in temporal coding, which is defined as phase-modulation of CA1 neurons by theta oscillation, for configural associative memory. Here, we investigated task-related neuronal activity in PFC, RSC, and CA1 during the cue-combination task, which requires the rat to associate odor and sound cues for making a correct choice. As the results, subsets of both RSC and PFC neurons were phase-modulated by CA1 theta oscillations, and these neurons showed synchronous firing activity with CA1 neurons during the task. These results suggest that temporal coding in hippocampus could be the global interaction across the hippocampal-cortical circuits.

Free Research Field

神経科学